Raphael Mechoulam Selected Research

Ovariectomy (Oophorectomy)

10/2019	HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity.
7/2015	CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency.
10/2010	Oleoyl serine, an endogenous N-acyl amide, modulates bone remodeling and mass.

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Raphael Mechoulam Research Topics

Disease

19	Nausea 12/2023 - 04/2002
16	Inflammation (Inflammations) 12/2022 - 12/2004
14	Neoplasms (Cancer) 12/2023 - 03/2003
12	Vomiting 02/2022 - 03/2003
9	Pain (Aches) 01/2023 - 12/2004
7	Schizophrenia (Dementia Praecox) 01/2022 - 01/2007
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 12/2005
7	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2019 - 10/2009
6	Infarction (Infarctions) 01/2019 - 08/2003
6	Multiple Sclerosis 01/2016 - 04/2006
5	Closed Head Injuries 01/2019 - 04/2005
5	Parkinson Disease (Parkinson's Disease) 08/2011 - 08/2003
4	Cognitive Dysfunction 01/2022 - 08/2007
4	Obesity 09/2021 - 01/2007
4	Epilepsy (Aura) 01/2020 - 01/2007
4	Osteoporosis 10/2019 - 01/2007
4	Neuroinflammatory Diseases 01/2019 - 05/2008
4	Huntington Disease (Huntington's Disease) 02/2013 - 01/2007
4	Hepatic Encephalopathy 09/2009 - 01/2006
3	Wounds and Injuries (Trauma) 01/2023 - 07/2008
3	Catalepsy 01/2023 - 10/2017
3	Hypothermia 01/2023 - 10/2017
3	COVID-19 10/2022 - 01/2021
3	Neuralgia (Stump Neuralgia) 01/2022 - 01/2020
3	Infections 01/2021 - 12/2018
3	Fibrosis (Cirrhosis) 09/2016 - 09/2009
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2016 - 05/2008
3	Reperfusion Injury 01/2016 - 05/2011
3	Liver Diseases (Liver Disease) 09/2009 - 01/2006
2	Substance-Related Disorders (Drug Abuse) 10/2023 - 01/2023
2	Osteoarthritis 01/2023 - 12/2022
2	Mental Disorders (Mental Disorder) 01/2023 - 05/2010
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 01/2022
2	Tobacco Use Disorder (Nicotine Dependence) 09/2020 - 01/2019
2	Body Weight (Weight, Body) 02/2020 - 03/2005
2	Sleepiness 01/2019 - 05/2008
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2016 - 12/2007
2	Ischemia 01/2016 - 05/2011
2	Experimental Arthritis 10/2015 - 03/2004

Drug/Important Bio-Agent (IBA)

45	CannabinoidsIBA 12/2023 - 02/2002
37	CannabidiolIBA 12/2023 - 04/2002
26	EndocannabinoidsIBA 10/2023 - 02/2002
10	Dronabinol (THC)FDA LinkGeneric 01/2023 - 01/2004
7	Lithium ChlorideIBA 12/2023 - 04/2002
7	cannabidiolic acidIBA 12/2023 - 07/2017
7	AntiemeticsIBA 02/2022 - 07/2004
6	Cannabinoid Receptors (Cannabinoid Receptor)IBA 12/2022 - 02/2007
6	Messenger RNA (mRNA)IBA 01/2021 - 05/2006
6	Glycerol (Glycerine)FDA LinkGeneric 05/2016 - 02/2002
5	HU 308IBA 01/2023 - 12/2008
5	AmidesIBA 02/2022 - 10/2018
5	CB2 Cannabinoid ReceptorIBA 01/2022 - 08/2009
5	EstersIBA 01/2021 - 01/2018
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 07/2008
5	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 01/2019 - 01/2004
5	Cannabinoid Receptor AgonistsIBA 01/2016 - 02/2002
5	Neuroprotective AgentsIBA 08/2011 - 02/2002
5	LithiumIBA 02/2008 - 03/2003
4	anandamide (arachidonylethanolamide)IBA 06/2022 - 02/2002
4	Morphine (MS Contin)FDA LinkGeneric 02/2022 - 02/2020
4	Fatty Acids (Saturated Fatty Acids)IBA 02/2022 - 01/2019
4	muskIBA 02/2022 - 01/2004
4	Naloxone (Narcan)FDA LinkGeneric 02/2022 - 02/2020
4	Anti-Anxiety Agents (Anxiolytics)IBA 01/2022 - 02/2013
4	quinone (benzoquinone)IBA 03/2021 - 07/2004
4	cannabidiol hydroxyquinone (HU331)IBA 03/2021 - 07/2006
4	Serine (L-Serine)FDA Link 10/2019 - 06/2015
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 02/2002
3	Alanine (L-Alanine)FDA Link 12/2023 - 09/2020
3	Therapeutic UsesIBA 10/2022 - 09/2009
3	Medical MarijuanaIBA 01/2022 - 01/2018
3	Antipsychotic Agents (Antipsychotics)IBA 01/2022 - 02/2013
3	HU-910IBA 01/2022 - 04/2012
3	N-oleoylglycineIBA 01/2021 - 01/2020
3	5-HT1A Serotonin ReceptorIBA 09/2020 - 06/2011
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 07/2006
3	AM 251 (AM251)IBA 01/2019 - 04/2012
3	3-nitrotyrosineIBA 01/2017 - 05/2011
3	CytokinesIBA 10/2015 - 05/2006
3	AntioxidantsIBA 02/2013 - 01/2004
3	glyceryl 2-arachidonate (2-arachidonoylglycerol)IBA 05/2011 - 04/2005
3	EmeticsIBA 01/2006 - 04/2002
2	Analgesics (Analgesic Drugs)IBA 12/2022 - 01/2006
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 02/2022 - 09/2020
2	Amphetamine (Amfetamine)FDA LinkGeneric 01/2022 - 01/2019
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2022 - 01/2022
2	Calcium Gluconate (CBG)IBA 09/2021 - 06/2011
2	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 01/2020
2	Antidepressive Agents (Antidepressants)IBA 01/2021 - 01/2019
2	HU-580IBA 09/2020 - 01/2018
2	Serotonin (5 Hydroxytryptamine)IBA 09/2020 - 08/2003
2	SaccharinIBA 09/2020 - 06/2011
2	Methylazoxymethanol AcetateIBA 01/2020 - 01/2019
2	LipidsIBA 10/2018 - 08/2011
2	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)IBA 01/2018 - 06/2011
2	Transaminases (Aminotransferases)IBA 01/2017 - 05/2011
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2015 - 05/2011

Therapy/Procedure

10	Therapeutics 01/2022 - 07/2006
8	Drug Therapy (Chemotherapy) 12/2023 - 04/2002
3	Ovariectomy (Oophorectomy) 10/2019 - 10/2010